Enhancement of Experimental Allergic Encephalomyelitis (EAE) by DNA Immunization with Myelin Proteolipid Protein (PLP) Plasmid DNA
نویسندگان
چکیده
منابع مشابه
enhancement of immune responses by co-delivery of ccl19/mip-3beta chemokine plasmid with hcv core dna/protein immunization
conclusions these results exhibited the immuno potentiator effects of mip-3beta plasmid when coadministrated with the hcv core dna vaccine. complimentary studies integrating mip-3beta as a genetic adjuvant in hcv-core-dna vaccination models are warranted. results mice covaccinated with mip-3beta elicited an enhanced th1 biased systemic immune response as evidenced by higher ifn-γ/il-4 and anti-...
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To understand the mechanism of Multiple Sclerosis (MS), an autoimmune demyelinating disease, the researchers developed an experimental animal model for MS, which is called EAE (Experimental Allergic Encephalomyelitis). There are several methods for inducing this animal model. In this research the active EAE, which is developed by injecting bovine myelin antigens into genetically susceptibl...
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Antibodies with a specificity for myelin, as demonstrated by immunofluorescence, are present in the sera of rabbits injected with spinal cord. These antibodies react with both adult rabbit and human spinal cord but not with unmyelinated areas of neonatal human spinal cord.
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Experimental allergic encephalomyelitis (EAE) is an autoimmune disease that can be induced in laboratory animals by immunization with the major myelin proteins, myelin basic protein (MBP) and proteolipid protein (PLP). We analyzed the role of the T cell receptor (TCR) repertoire in susceptibility to EAE induced by these two autoantigens. Autoreactive T cells induced after immunization with MBP ...
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ژورنال
عنوان ژورنال: Journal of Neuropathology & Experimental Neurology
سال: 1998
ISSN: 0022-3069,1554-6578
DOI: 10.1097/00005072-199808000-00005